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Article: Your Gut Microbiome: The Tiny Organisms That Run the Show

Field of flowers representing the microbiome

Your Gut Microbiome: The Tiny Organisms That Run the Show

Your Gut Has Roommates—Trillions of Them

So far in our Gut Health Series, we’ve taken you through the full digestive journey—starting with how your body breaks food down (Blog 1), why stomach acid and enzymes are essential (Blog 2), and how your gut lining keeps the good in and the bad out (Blog 3).


Now, we’re diving into the part of gut health everyone talks about—but often oversimplifies:

🦠 The microbiome


Yes, you’ve likely heard all the buzz—probiotics, fermented foods, “gut-friendly” everything. But what exactly is the microbiome? And how does it actually impact your health?

Meet Your Microbial Side

Your gut microbiome is a vast, diverse community of trillions of microbes—bacteria, fungi, viruses, and even yeasts—that mostly live in your large intestine. You coexist with them in a (mostly) peaceful, symbiotic relationship. And when that community is diverse and in balance, they support your digestion, immunity, metabolism, and even your mood.


Think of it as your internal ecosystem. When it thrives, so do you. When it’s out of whack? You feel it—sometimes in subtle ways, and sometimes in symptoms you’d never guess were linked to your gut.

A healthy, balanced microbiome helps:

  • Break down fiber into short-chain fatty acids to fuel your gut lining and reduce inflammation

  • Produce essential vitamins like B12, K2, and folate

  • Support your immune system and help it respond appropriately

  • Influence neurotransmitter production (like serotonin and dopamine)

  • Keep harmful microbes in check

  • Play a role in metabolism, hormones, and even weight regulation


Your microbes may be small—but their impact is anything but.

What Throws Your Microbiome Off Balance?

Your microbiome is a dynamic filter between you and the outside world. When that filter is off, your whole system feels it.


Everything you bring into your body will either help your microbiome or hurt it. Unfortunately, our modern lifestyles are not very friendly to our microbiome, so it’s good to understand what can impact its happiness.

Here are some of the microbiome's biggest disruptors:

  • Antibiotics and common meds like antacids, birth control, and NSAIDs

  • Diets low in fiber and high in processed food

  • Refined sugars and artificial sweeteners

  • Not enough plant diversity in your meals

  • Chronic stress, poor sleep, and constantly being “on”

  • Alcohol, smoking, and everyday toxin exposure

  • Over-sanitized environments that limit healthy microbial exposure


Noticing a pattern? Stress, processed foods, alcohol, and certain meds can be seriously detrimental to every aspect of gut health!

woman pouring alcoholic drink
Signs your microbiome may be out of balance:
  • Bloating, gas, constipation, or diarrhea
  • Frequent illness or food sensitivities
  • Skin issues like eczema or acne
  • Mood swings, anxiety, or brain fog
  • Fatigue, inflammation, or unexplained weight gain

Signs your microbiome may be out of balance:

  • Bloating, gas, constipation, or diarrhea
  • Frequent illness or food sensitivities
  • Skin issues like eczema or acne
  • Mood swings, anxiety, or brain fog
  • Fatigue, inflammation, or unexplained weight gain

Your Gut and Brain Are in Constant Conversation

Your microbiome doesn’t just influence digestion—it has a direct line to your brain via the gut-brain axis, a two-way communication network between your gut and your central nervous system.


A healthy gut microbiome helps:

  • Regulate the production of neurotransmitters like serotonin (about 90% of it is made in the gut!), dopamine, and GABA, which impact mood, focus, sleep, and stress response
  • Calm the nervous system—helping you feel grounded instead of reactive
  • Modulate stress hormones like cortisol
  • Reduce systemic inflammation linked to anxiety, depression, and brain fog

When your microbiome is out of balance, you may notice:

  • Mood swings or irritability
  • Brain fog or trouble focusing
  • Feelings of anxiety, overwhelm, or low motivation

If your mental health feels “off,” your gut might be the first place to check in.

Where Gut Microbes Live—and Where They Shouldn’t

While microbes can be found throughout the body (skin, lungs, reproductive system), the majority live throughout your digestive system. In a healthy gut, the majority of your microbiome lives in the large intestine (colon)—where they help break down fiber, produce short-chain fatty acids, and support immune and gut lining health.

Here’s where your microbes are normally found:

  • Mouth: Diverse microbes that begin digestion and play a key role in oral and whole-body health
  • Stomach: Very few microbes—thanks to stomach acid that keeps this area highly acidic and mostly sterile
  • Small intestine: Some microbes live here (especially toward the end), but in low numbers
  • Large intestine (colon): This is where the real microbial action happens—trillions of diverse microbes thrive here
Gut microbes

This natural setup keeps digestion efficient, nutrient absorption smooth, and immune reactions in check.

What Happens When Microbes End Up Where They Don’t Belong?

When bacteria that are meant to live in the large intestine start to overgrow in the small intestine, you end up with a condition called SIBO (Small Intestinal Bacterial Overgrowth).


In this part of the gut, nutrients are still being absorbed—and bacteria fermenting food too early in the process causes problems like:

  • Bloating, especially after meals
  • Gas, burping, or cramping
  • Malabsorption of nutrients
  • Food sensitivities or reactivity
  • Brain fog, fatigue, or skin issues

Why does this happen?

  • Low stomach acid
  • Slow movement of food through gut
  • Previous food poisoning or gut infections
  • Chronic stress
  • Medications (PPIs, antibiotics)
Bloated woman in pain

In this part of the gut, nutrients are still being absorbed—and bacteria fermenting food too early in the process causes problems like:

  • Bloating, especially after meals
  • Gas, burping, or cramping
  • Malabsorption of nutrients
  • Food sensitivities or reactivity
  • Brain fog, fatigue, or skin issues

Why does this happen?

  • Low stomach acid
  • Slow movement of food through gut
  • Previous food poisoning or gut infections
  • Chronic stress
  • Medications (PPIs, antibiotics)
Bloated woman in pain

Tip: A balanced microbiome isn’t just about the types of microbes you have—it’s also about where they live and how they behave.

How to Support a Thriving Gut Microbiome

The good news? Your microbiome is incredibly responsive to your daily choices. Here’s how to show it some love:

1. Feed It

  • Eat a variety of colorful, fiber-rich plants (aim for 20–30 different varieties per week)
  • Include fermented foods like sauerkraut, kimchi, yogurt, and kefir
  • Add prebiotic-rich foods (onion, garlic, leeks, asparagus, bananas, flaxseed)

2. Protect It

  • Avoid unnecessary antibiotics and ultra-processed foods
  • Cut down on alcohol, artificial sweeteners, and excess sugar
  • Choose clean, low-toxin food and water when possible

3. Regulate It

  • Prioritize sleep and rest—your gut microbes follow a circadian rhythm too
  • Reduce stress through breathwork, movement, nature, or stillness
  • Get outside and let your body interact with the real world—microbial exposure isn’t something to fear

Prebiotics, Probiotics, and Postbiotics: What’s the Difference?

When it comes to gut health, these three often get tossed around together—but they each play a distinct role:


🥦 Prebiotics
Think of prebiotics as microbe food. They’re certain types of fiber (found in plants!) that your beneficial gut bacteria ferment to stay alive and thriving. Examples include garlic, onions, leeks, bananas, oats, apples, and asparagus. A diverse, plant-rich diet is your best source.


🦠 Probiotics
These are the actual live microbes—the good bacteria—that support gut health. You’ll find them in fermented foods like yogurt, kefir, sauerkraut, kimchi, and miso. Supplementing with probiotics can also help in some cases, but they’re not a one-size-fits-all solution.


 Postbiotics
These are the beneficial byproducts created when your gut bacteria break down prebiotic fibers. Think short-chain fatty acids (like butyrate), which help maintain the gut lining, regulate inflammation, and support immune health. You can’t eat postbiotics directly—they’re made inside your gut.


Bottom line?
Prebiotics feed the probiotics, and together they create postbiotics. Supporting all three is the key to a resilient, balanced microbiome—and whole foods are one of the best ways to do just that.

Choosing a Probiotic (If You Need One)

Whole foods and lifestyle shifts should always be your foundation—but sometimes your gut needs more targeted support. That’s where probiotics come in.


Supplements can help, especially if your microbiome has been disrupted by antibiotics, illness, or stress. But not all probiotics are the same—specific strains offer specific benefits

Top strains to look for include:

What Happens When You Rebalance the Microbiome?


When your gut bugs are back in sync, your entire system benefits:

  • Digestion improves
  • Bloating and food sensitivities fade
  • Inflammation calms
  • Energy and mood lift
  • Immunity strengthens
  • Skin clears
Woman meditating outdoors

When your gut bugs are back in sync, your entire system benefits:

  • Digestion improves
  • Bloating and food sensitivities fade
  • Inflammation calms
  • Energy and mood lift
  • Immunity strengthens
  • Skin clears
Woman meditating outdoors

What Happens Next?

We’ve explored how the trillions of microbes in your gut shape your digestion, immunity, and mood. But what do those microbes actually run on?


UP NEXT  ⏭️  In our next post, we’ll zoom in on food—the everyday choices that either nourish or disrupt your microbiome. From fiber to polyphenols, we’ll explore why variety matters, how soil health affects nutrient density, and why real, whole foods may be the most powerful tool for gut balance.

TAKEAWAY 👉🏼 Your microbiome is a fundamental part of your health. When it’s thriving, so are you. And the beautiful part? You don’t need perfection. Just small, consistent choices that nourish your body and gut—every single day.

Ashley Lizotte, MS

Author: Ashley Lizotte, MS

Ashley is one of the co-founders of Farmana. She has her Masters in Nutrition and has spent nearly 20 years of her career in the health and wellness industry, working closely with functional medicine practitioners to formulate therapeutic dietary supplements and develop treatment protocols. Ashley spends most of her time perusing the local farmer's markets, perfecting her sourdough, working out, tending to her garden, trying new recipes, and going on long walks with her Wirehaired Vizsla, Birdie.

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